Denise M. Scholtens

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

Examining the impact of gestational diabetes genetic susceptibility variants on maternal glucose levels during and post-pregnancy

This study examines how genetic variants linked to gestational diabetes affect maternal glucose levels during and after pregnancy, finding consistent associations with fasting glucose but varying effects on postprandial glucose.

SpiderLearner: An ensemble approach to Gaussian graphical model estimation

SpiderLearner combines multiple Gaussian graphical model methods to create an ensemble estimate, improving performance and identifying a seven-gene risk score for ovarian cancer.

Genetic effects on the timing of parturition and links to fetal birth weight

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

The paper examines the effect of fetal genetic predispositions to metabolically favourable adult adiposity and BMI on birth weight and other anthropometric traits, finding stronger associations with birth weight for the adiposity alleles.

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

This study uses Mendelian Randomisation to show that maternal metabolically favourable adiposity is associated with lower offspring birth weight compared to general adiposity indexed by BMI.

All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes

The paper examines how different glucose thresholds for gestational diabetes identify women with higher genetic risk for type 2 diabetes using genetic scores.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.