Luigi Bouchard

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

Development of a microRNA clock for gestational age in the general population

This paper develops a miRNA-based gestational age clock (miRClock-GA) using cord blood plasma miRNA data and validates it in an independent cohort, showing associations with birthweight and childhood BMI.

Genetic and molecular analyses of candidate germline BRIP1/FANCJ variants implicated in breast and ovarian cancer

The paper investigates five BRIP1/FANCJ variants for their clinical relevance in breast and ovarian cancer, finding three likely damaging variants associated with cellular sensitivity to chemotherapy drugs.

Examining the impact of gestational diabetes genetic susceptibility variants on maternal glucose levels during and post-pregnancy

This study examines how genetic variants linked to gestational diabetes affect maternal glucose levels during and after pregnancy, finding consistent associations with fasting glucose but varying effects on postprandial glucose.

Rare diseases load through the study of a regional population

This study identifies rare genetic variants in a Quebec population with a founder effect, validates known variants, discovers new ones, and highlights their clinical relevance.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Genetic effects on the timing of parturition and links to fetal birth weight

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

Identification and application of plasmatic microRNA expression quantitative trait loci (miR-QTL) at first trimester of pregnancy

The paper identifies miRNA expression quantitative trait loci (miR-QTL) in pregnancy and links them to pregnancy complications using genetic risk scores.

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

This study identifies placental DNA methylation changes linked to maternal smoking during pregnancy and their associations with birth outcomes using data from the PACE consortium.

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

Placenta DNA Methylation Adaptation to Maternal Glucose Tolerance in Pregnancy

The paper investigates DNA methylation changes in placental tissue linked to maternal glucose response during pregnancy, identifying CpG sites associated with gene expression.

An analytic approach for interpretable predictive models in high dimensional data, in the presence of interactions with exposures

The paper introduces ECLUST, a framework that improves predictive modeling in high-dimensional data by incorporating exposure-dependent clustering, showing better performance than traditional methods.

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.

Maternal and fetal genetic contribution to gestational weight gain

This study investigates the genetic contributions to gestational weight gain, finding that maternal common variants explain about 20% of variability, while fetal variants have a minor role.