Author

Jessica Eira

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do PortoORCID 0000-0002-8273-9735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Joana MagalhãesiD· 2 shared Márcia A. LiziD· 2 shared Ana Isabel SeixasiD· 1 shared Andreia DiasiD· 1 shared Carolina LemosiD· 1 shared Estefânia CarvalhoiD· 1 shared Francesca BartoliniiD· 1 shared Guilherme Nóvoa· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersNeuroscience

Joana MagalhãesORCID

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2 papers

Recent·Most cited

Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy

Joana Magalhães, Vítor Pacheco Dias, Jessica Eira, Marina I. Oliveira da Silva, Guilherme Nóvoa, Margarida Martins, Hung‐Wei Kan, Andreia Dias, Estefânia Carvalho, Mariana Santos, Ana Isabel Seixas, Teresa Coelho, Ricardo Jorge Ferreira Taipa, Joana Paes de Faria, Carolina Lemos, , Márcia A. Liz

This study shows that Rac1 inhibition prevents cytoskeletal dysfunction in ATTRv-PN by rescuing axonal defects in mice and supporting its therapeutic potential in patients.

Cell Reports · Oct 1, 2025Peer-reviewedNeuroscience

Transthyretin promotes axon growth via regulation of microtubule dynamics and tubulin acetylation

Jessica Eira, Joana Magalhães, Nídia Macedo, Maria Elena Pero, Thomas Misgeld, Mónica Mendes Sousa, Francesca Bartolini, Márcia A. Liz

This study shows that Transthyretin (TTR) promotes axon growth by regulating microtubule dynamics and tubulin acetylation, with restoration of acetylated tubulin rescuing defects in TTR knockout mice.

Frontiers in Cell and Developmental Biology · Nov 8, 2021Peer-reviewedNeuroscience