Mónica Mendes Sousa

In vitro programming and pseudounipolarization of human iPSC-derived sensory neurons

This study demonstrates the generation of functional human sensory neurons from iPSCs using NBI factors, showing their electrophysiological properties and disease relevance.

Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons

This study identifies an axon-specific microtubule-associated protein signature that drives asymmetric regeneration in sensory neuron axons, using an in vitro model of DRG neurons.

HDAC-6 inhibition ameliorates the early neuropathology in a mouse model of Krabbe disease

This study shows that HDAC6 inhibition with ACY-738 improves early neuropathology and neuronal defects in a mouse model of Krabbe disease.

Neuronal cultures show bidirectional axonal conduction with antidromic action potentials depolarizing the soma

The paper shows that EAPs and antidromic conduction occur in neuronal cultures and can depolarize the soma, suggesting functional roles in neuronal activity.

Transthyretin promotes axon growth via regulation of microtubule dynamics and tubulin acetylation

This study shows that Transthyretin (TTR) promotes axon growth by regulating microtubule dynamics and tubulin acetylation, with restoration of acetylated tubulin rescuing defects in TTR knockout mice.