Patient-Derived Xenograft-Guided Prediction of Chemotherapy Response in Triple-Negative Breast Cancer
Jonathan Thomas Lei, Lacey Elizabeth Dobrolecki, Chen Lu Huang, Ramakrishnan Rajaram Srinivasan, Suhas V. Vasaikar, Alaina N. Lewis, Christina Sallas, Na Zhao, Jin Cao, John David Landua, Jacob B. Pilcher, Chang In Moon, Yuxing Liao, Susan Galloway Hilsenbeck, Mothaffar Fahed Rimawi, , Michael T. Lewis
This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.
bioRxiv · Dec 9, 2024 · PreprintCancer Biology