Author

Tomoko Ozawa

University of California, San FranciscoORCID 0000-0002-8529-4575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

David Ronan RaleighiD· 3 shared Kyounghee Seo· 3 shared Mitchel Stuart BergeriD· 3 shared Jacob S. YoungiD· 2 shared Joanna J. PhillipsiD· 2 shared Joanna Pak· 2 shared Kanish MirchiaiD· 2 shared Siyuan John LiuiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenomics

David Ronan RaleighORCID

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3 papers

Recent·Most cited

IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma

Jacob S. Young, Nam Woo Cho, Calixto‐Hope G. Lucas, Hinda Najem, Kanish Mirchia, William C. Chen, Courtney M. Tamaki, Harrshavasan Congivaram, Kyounghee Seo, Naomi Zakimi, Vikas Daggubati, Tim Casey-Clyde, Minh P. Nguyen, Zhenhong Chen, Joanna J. Phillips, , David Ronan Raleigh

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

Cancer Research · Apr 13, 2026Peer-reviewedCancer Biology

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma

Siyuan John Liu, Christopher Zou, Joanna Pak, A. P. Morse, Dillon Pang, Timothy Casey-Clyde, Ashir A. Borah, David Wu, Kyounghee Seo, Thomas O’Loughlin, Daniel A. Lim, Tomoko Ozawa, Mitchel Stuart Berger, Roarke A. Kamber, William A. Weiss, , Luke A. Gilbert

This study uses in vivo perturb-seq to analyze gene function and radiotherapy responses in glioblastoma by targeting cancer and microenvironment cells.

Genome biology · Oct 7, 2024Peer-reviewedGenomics

Multiplatform molecular profiling and functional genomic screens identify prognostic signatures and mechanisms underlying MEK inhibitor response in somatic NF1 mutant glioblastoma

Sixuan Pan, Kanish Mirchia, Emily Payne, Siyuan John Liu, Nadeem N. Al-Adli, Zain Peeran, Poojan D. Shukla, Jacob S. Young, Rohit K. Gupta, Jasper Wu, Joanna Pak, Kyounghee Seo, Tomoko Ozawa, Brian S Na, Alyssa Terry Reddy, , Harish N. Vasudevan

bioRxiv · Jul 1, 2024 · PreprintGenomics