José A. Morais

Serum C-terminal agrin fragment as a biomarker of age-related neuromuscular decline in men: influence of physical activity

This study finds that serum C-terminal agrin fragment (CAF) increases with age and is linked to neuromuscular decline and reduced physical function, with physical activity mitigating these effects in older men.

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.