Pierrette Gaudreau

Serum C-terminal agrin fragment as a biomarker of age-related neuromuscular decline in men: influence of physical activity

This study finds that serum C-terminal agrin fragment (CAF) increases with age and is linked to neuromuscular decline and reduced physical function, with physical activity mitigating these effects in older men.

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.

Engaging the complexity of diet and healthy aging in humans

This study uses nutritional geometry to analyze how dietary patterns affect aging in 1560 older adults, finding that optimal nutrient levels are often intermediate and context-dependent.

The frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems

This study investigates frailty as an emergent property of physiological system dysregulation using Mahalanobis distance in two older adult cohorts, finding partial support for breadth and nonlinearity of associations.