The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Neuron · Jun 13, 2025Peer-reviewedNeuroscience

High-throughput measurements of neuronal activity in single human iPSC-derived glutamate neurons

Isabel Gameiro‐Ros, Ádám Jonatán Tengölics, Iya Prytkova, Chella Kamarajan, Zhiping P. Pang, Alison Goate, Ronald P. Hart, Paul A. Slesinger

This paper develops a high-throughput method to measure neuronal activity in human iPSC-derived glutamatergic neurons using Mg2+-free ACSF and confirms donor-specific firing patterns.

bioRxiv · Apr 7, 2025 · PreprintNeuroscience

Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons

Iya Prytkova, Yiyuan Liu, Michael B. Fernando, Isabel Gameiro‐Ros, Dina Popova, Chella Kamarajan, Xiaoling Xuei, David Balin Chorlian, Howard J. Edenberg, Jay A. Tischfield, Bernice Porjesz A, Zhiping P. Pang, Ronald P. Hart, Alison Goate, Paul A. Slesinger

The paper investigates how upregulated GIRK2 affects ethanol-induced changes in human neurons, showing it counteracts excitability and respiration changes.

Journal of Neuroscience · Feb 13, 2024Peer-reviewedNeuroscience

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

Dina Popova, Isabel Gameiro‐Ros, Mark M. Youssef, Petronio D. Zalamea, Ayeshia Morris, Iya Prytkova, Azadeh Jadali, Kelvin Y. Kwan, Chella Kamarajan, Jessica E. Salvatore, Xiaoling Xuei, David Balin Chorlian, Bernice Porjesz A, Samuel Kuperman C, Danielle M. Dick, , Ronald P. Hart

This study shows that KCNJ6 noncoding variants increase excitability in human glutamatergic neurons, an effect reversed by ethanol exposure.

Molecular Psychiatry · Oct 7, 2022Peer-reviewedNeuroscience