Joshua R. Huot

Chemotherapy induces tissue NAD+ loss, and downregulation of NAD+ biosynthetic enzyme Nrk2 marks muscle wasting

This study shows chemotherapy causes NAD+ loss in muscle and liver, with Nrk2 downregulation linked to muscle wasting across multiple models.

Empagliflozin preserves cardiac function and modulates metabolism in a mouse model of Duchenne muscular dystrophy

This study shows empagliflozin improves cardiac function and mitochondrial health in a mouse model of Duchenne muscular dystrophy.

Deficient Cardiolipin Remodeling Alters Muscle Fiber Composition and Neuromuscular Connectivity in Barth Syndrome

This study shows that Tafazzin deficiency in skeletal muscle causes neuromuscular remodeling, including fiber type shifts and motor unit loss, without resting energetic failure.

Klotho deficiency promotes skeletal muscle weakness and is associated with impaired motor unit connectivity

This study shows Klotho deficiency causes skeletal muscle weakness and impaired motor unit connectivity by altering neuromuscular junction structure and function.

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice

This study shows GL261 glioblastoma tumors in young mice reduce skeletal muscle growth, mass, and protein synthesis while altering catabolism signaling.