Author

Manuel Palacín

Centre for Biomedical Network Research on Rare DiseasesORCID 0000-0002-8670-293XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Susanna BodoyiD· 2 shared Adrià Nicolàs-AragóiD· 1 shared Aída OrmazábaliD· 1 shared António ZorzanoiD· 1 shared Barbara SiriiD· 1 shared Carlo Dionisi‐ViciiD· 1 shared Cian J Lynch· 1 shared David SebastiániD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Susanna BodoyORCID

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2 papers

Recent·Most cited

Conserved Lysine in transmembrane helix 5 is key for the inner gating of the LAT transporter BasC

Joana Fort, Adrià Nicolàs-Aragó, Luca Maggi, Maria Martinez Molledo, Despoina Kapiki, Paula González-Novoa, Patricia Gómez-Gejo, Niels Zijlstra, Susanna Bodoy, Els Pardon, Jan Steyaert, Óscar Llorca, Modesto Orozco, Thorben Cordes, Manuel Palacín

This study identifies a conserved lysine in TM5 of BasC as critical for cytoplasmic gate dynamics, showing its role in gating transitions and modulation by substrates and mutations.

PNAS Nexus · Dec 23, 2024Peer-reviewedBiochemistry

Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis and iron homeostasis

Judith Giroud‐Gerbetant, Fernando Sotillo, Gonzalo Hernández, Cian J Lynch, Irene Ruano, Barbara Siri, David Sebastián, António Zorzano, Rafael Artuch, Aída Ormazábal, Mayka Sánchez, Günter Weiß, Neus Prats, Carlo Dionisi‐Vici, Manuel Serrano, , Susanna Bodoy

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.

bioRxiv · Aug 15, 2021 · PreprintMolecular Biology