Author

Thomas Robert Jahn

German Cancer Research CenterORCID 0000-0002-9266-6736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Carmen I. Nussbaum-KrammeriD· 2 shared Ann-Christin Krahl· 1 shared Annabelle SchlüteriD· 1 shared Anne S. WentinkiD· 1 shared Axel MogkiD· 1 shared Bernd BukauiD· 1 shared Carl Alexander SandhofiD· 1 shared Christopher J. H. ElliottiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Carmen I. Nussbaum-KrammerORCID

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Author profile →

3 papers

Recent·Most cited

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

Carl Alexander Sandhof, Nicole Martin, Jessica Tittelmeier, Annabelle Schlüter, Martina Pezzali, David C. Schöndorf, Timo Lange, Peter Reinhardt, Janina S. Ried, Siwen Liang, Gamze Uzunoğlu, Laura Gasparini, Thomas Robert Jahn, Dagmar E. Ehrnhoefer, Carmen I. Nussbaum-Krammer

Autophagy · Aug 25, 2025Peer-reviewedCell Biology

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5/mortalin in Drosophila

Jun‐yi Zhu, Shabab B. Hannan, Nina M. Dräger, Natalia Vereshchagina, Ann-Christin Krahl, Yulong Fu, Christopher J. H. Elliott, Zhe Han, Thomas Robert Jahn, Tobias M. Rasse

The paper investigates the role of Hsc70-5/mortalin loss in Drosophila Parkinson disease models and shows that autophagy inhibition rescues multiple phenotypes.

Autophagy · Jan 6, 2021Peer-reviewedGenetics

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

Eliana Nachman, Anne S. Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren S. J. Allinson, Harm H. Kampinga, William A. McEwan, Thomas Robert Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen I. Nussbaum-Krammer

This study shows that the Hsp70 disaggregation machinery disassembles Tau fibrils, generating small seeding-competent Tau species that can drive aggregation.

Journal of Biological Chemistry · May 28, 2020Peer-reviewedMolecular Biology