Shaomeng Wang

Lactate epigenetically shapes tumor cell states in H3K27M diffuse midline gliomas

This study shows lactate epigenetically regulates cell states in H3K27M diffuse midline gliomas by modifying histones, and targeting CBP/p300 reduces tumor heterogeneity and improves preclinical outcomes.

Rewiring Oncogenic Transcriptional Complexes with Domain-ALTerAtion Chimeras (DALTACs) in Prostate Cancer

A bifunctional AR–p300/CBP molecule, DALTAC-1, forces a non-native contact between AR and p300 domains, silences AR enhancers and regresses AR-driven prostate tumors in mice while sparing AR-negative lines.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors

This study evaluates the signaling inhibition index (SII) of various RAS-targeted inhibitors across RAS-mutant and wild-type models, revealing significant variability in their effectiveness and selectivity.

Proteolysis-targeting vaccines (PROTAVs) for robust combination immunotherapy of melanoma

This paper introduces PROTAVs, a new vaccine strategy that enhances T cell responses and combination immunotherapy for melanoma by improving antigen processing and cross-presentation.