Author

Jen Kok

NSW Health PathologyORCID 0000-0002-8796-283XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Vitali SintchenkoiD· 3 shared Alexander A. KhromykhiD· 2 shared Anthony Dominic KelleheriD· 2 shared Anupriya AggarwaliD· 2 shared Camille EsneauiD· 2 shared Carl J. E. SusteriD· 2 shared Cesar L. MorenoiD· 2 shared Christina FichteriD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

Vitali SintchenkoORCID

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4 papers

Recent·Most cited

COSMOS: integrated vector-pathogen metagenomics for mosquito-borne disease

Annie J Forster, Adil A Khan, Emma Garrett, Cheryl Toi, Carl JE Suster, John Haniotis, Kai Dang, Jack Watson, Stephen Doggett, Sharon C-A Chen, Matthew R Watts, Jen Kok, Vitali Sintchenko, Michael Payne, Cameron Webb, , Tanya Golubchik

COSMOS integrates vector-pathogen metagenomics to monitor mosquito-borne diseases, detecting pathogens and mosquito communities in field samples with high accuracy.

bioRxiv · Nov 4, 2026 · PreprintMicrobiology

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison, Christina Fichter, Vanessa Milogiannakis, Madeeha Afzal, Alberto Ospina-Stella, Daniel Asarnow, Angelica L. Morgan, Shafagh A. Waters, Till Böcking, Boaz Ng, Camille Esneau, Nathan Bartlett, Atharva Naik, , Stuart Grant Turville

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

bioRxiv · Sep 24, 2026 · PreprintMicrobiology

Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.

Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison, Christina Fichter, Vanessa Milogiannakis, Madeeha Afzal, Alberto Ospina Stella, Shafagh A. Waters, Camille Esneau, Nathan Wylie Bartlett, Stefan Pöhlmann, Markus Hoffmann, Louise M. Burrell, Sheila K. Patel, Sally Ellis, , Stuart Grant Turville

This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.

bioRxiv · Jul 7, 2025 · PreprintMicrobiology

A laboratory framework for ongoing optimisation of amplification based genomic surveillance programs

Connie Lam, Jessica C. Johnson-Mackinnon, Kerri Basile, Winkie Fong, Carl J. E. Suster, Mailie L. Gall, Jessica E. Agius, Shona Chandra, Jenny L. Draper, Elena M. Martinez, Alexander P. Drew, Qinning Wang, Sharon Chia-Ju Chen, Jen Kok, Dominic Edmund Dwyer, , Rebecca J. Rockett

This study develops a framework to optimize sequencing efficiency for genomic surveillance by adjusting primer pooling and sets based on evolving viral populations.

bioRxiv · Jul 17, 2023 · PreprintGenomics