Matthew J. Blow

Adaptive laboratory evolution rewires Pseudomonas putida for resource-efficient acetate assimilation

This study improves acetate tolerance in Pseudomonas putida through adaptive laboratory evolution and identifies gacA and fabB as key targets for efficient acetate assimilation.

Multi-omic integration using interpretable machine learning reveals genetic mechanisms of trait variation and phenotypic plasticity in switchgrass

This study integrates multi-omic data with interpretable machine learning to identify genetic mechanisms underlying trait variation and phenotypic plasticity in switchgrass across environments.

Multi-season analysis reveals hundreds of drought-responsive genes in sorghum

This study identifies hundreds of drought-responsive genes in sorghum using multi-season transcriptomic data from field experiments.

scMicrobe PTA: Near Complete Genomes From Single Bacterial Cells

This study introduces PTA, a single-cell amplification technique that produces nearly complete bacterial genomes and improves viral and gene cluster recovery compared to standard methods.

Cell Type- and Tissue-specific Enhancers in Craniofacial Development

The paper identifies 14,000 human craniofacial enhancers across developmental stages and shows 56% are conserved in mice, providing cell type- and stage-specific activity profiles.

Genome-Wide Fetalization of Enhancer Architecture in Heart Disease

The paper identifies widespread epigenomic changes in idiopathic dilated cardiomyopathy, showing a shift toward fetal-like enhancer states and providing a data resource for further study.

Topologically Associating Domain Boundaries are Commonly Required for Normal Genome Function

This study shows that deleting TAD boundaries in mice often causes molecular or developmental phenotypes, highlighting their importance for genome function.