Laura A. Vella

Tfh dysfunction is associated with poor responses to HBV vaccination

HBV vaccine-draining lymph node biopsies tie low antibody titers to reduced, interferon-skewed GNG4+ germinal center T follicular helper cells; public B cell clonotypes did not track response.

Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease

This study identifies disrupted lymphocyte chemotaxis in idiopathic multicentric Castleman disease, linking dysregulated chemokine production to germinal center dysfunction and lymphadenopathy.

Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans

The paper identifies GNG4 as a marker for activated CD4 T follicular helper cells in human germinal centers using multimodal single-cell analysis.

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.