Irene Martínez‐Gallego

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

This study shows that AM6545 treatment improves cognitive deficits in FX mice by modulating serotonergic receptors and gut microbiota.

Mitochondrial pyruvate import in astrocytes links anaplerosis to seizure resistance

This study shows that mitochondrial pyruvate import in astrocytes is essential for maintaining neurotransmitter homeostasis and seizure resistance, rather than primarily for bioenergetic purposes.

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer disease mice

This study investigates how β-amyloid and tau pathologies affect different neural circuits in a novel Alzheimer's disease mouse model, revealing region-specific synaptic, behavioral, and molecular changes.

Astrocytes mediate two forms of spike timing-dependent depression at entorhinal cortex-hippocampal synapses

The paper identifies two forms of spike timing-dependent long-term depression at EC-DG synapses, both requiring astrocytic mechanisms but differing in their molecular requirements.

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naive mice

This study shows that sub-chronic peripheral CB1R inhibition improves memory and executive function in mice and alters hippocampal synaptic plasticity and gene expression.

Arg1+ microglia are critical for shaping cognition in female mice

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.