Virginie Marcel

Translatome and translation dynamics analysis of a RiboCancer cell line panel reveals that leukemia-associated Rps15 mutations rewire translation through codon-specific tRNA accommodation defects.

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

SnoBIRD: A tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes

SnoBIRD identifies and refines C/D box snoRNA annotations across eukaryotes by distinguishing expressed snoRNAs from pseudogenes.

A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

Ribosome biogenesis is a therapeutic vulnerability in paediatric neuroblastoma

This study investigates ribosome biogenesis as a therapeutic target in neuroblastoma, showing that inhibiting RNA polymerase I reduces cell proliferation and induces apoptosis.

Targeting a shared neoepitope derived from non-canonical translation of c-MYC oncogene in cancer cells

The paper identifies a shared neoepitope from non-canonical c-MYC translation in cancer cells that activates T cells to kill tumors without harming normal cells.