Damien D’Amours

Smc5/6 - microtubules binding shapes pericentromeric chromatin

This study shows that Smc5/6 microtubule binding constrains chromatin dynamics and promotes pericentromeric folding in yeast, safeguarding genome stability during mitosis.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

Centrosomes act as organizing centers to promote Polo kinase-mediated adaptation to persistent DNA damage

The paper shows centrosomes organize Polo kinase (Cdc5) to adapt to DNA damage by phosphorylating SPB components, bypassing cell cycle arrest.

The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction

This study investigates how the Polo kinase Cdc5 is regulated during adaptation to telomere dysfunction in yeast, showing that its levels and phosphorylation status are critical for maintaining long-term cell cycle arrest.