Author

Jivan Khlghatyan

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jean‐Martin BeaulieuiD· 4 shared Aleksandra Marakhovskaia· 2 shared Alessandro BertolinoiD· 1 shared Alesya EvstratovaiD· 1 shared Alfonso MonacoiD· 1 shared Annalisa LellaiD· 1 shared Antonio RampinoiD· 1 shared Beata Henry· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersNeuroscience

Jean‐Martin BeaulieuORCID

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Author profile →

5 papers

Recent·Most cited

A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing

Giulio Pergola, Antonio Rampino, Leonardo Sportelli, Christopher Borcuk, Roberta Passiatore, Pasquale Di Carlo, Aleksandra Marakhovskaia, Leonardo Fazio, Nicola Amoroso, Mariana Nair Castro, Enrico Domenici, Massimo Gennarelli, Jivan Khlghatyan, Gianluca Christos Kikidis, Annalisa Lella, , Alessandro Bertolino

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging · Nov 22, 2023Peer-reviewedNeuroscience

Patient brain organoids identify a link between the 16p11.2 copy number variant and the RBFOX1 gene.

Milos Kostic, Joseph J. Raymond, Christophe A. C. Freyre, Beata Henry, Tayfun Tumkaya, Jivan Khlghatyan, Jill Dvornik, Jingyao Li, Jack S. Hsiao, Seon Hye Cheon, Jonathan Chung, Yishan Sun, Ricardo E. Dolmetsch, Kathleen A. Worringer, Robert J. Ihry

The paper uses patient brain organoids to show that 16p11.2 CNVs affect RBFOX1 expression and link it to neurodevelopmental disorders.

ACS Chemical Neuroscience · Oct 30, 2023Peer-reviewedNeuroscience

Fxr1 regulates sleep and synaptic homeostasis

Jivan Khlghatyan, Alesya Evstratova, Lusiné Bozoyan, Simon Chamberland, Dipashree Chatterjee, Aleksandra Marakhovskaia, Tiago Soares Silva, Katalin Tóth, Valérie Mongrain, Jean‐Martin Beaulieu

This study shows Fxr1 is downregulated during synaptic scaling and sleep deprivation, linking it to homeostatic plasticity and sleep regulation.

The EMBO Journal · Sep 7, 2020Peer-reviewedNeuroscience

CRISPR/Cas9 mediated intersectional knockout of GSK3β in D2 receptor expressing mPFC neurons reveals contributions to emotional regulation

Jivan Khlghatyan, Jean‐Martin Beaulieu

This study uses CRISPR/Cas9 to knockout GSK3β in D2 receptor expressing mPFC neurons, revealing its role in emotional regulation and behavior.

The CRISPR Journal · Jun 1, 2020Peer-reviewedNeuroscience

High sensitivity mapping of cortical dopamine D2 receptor expressing neurons

Jivan Khlghatyan, Clémentine Quintana, Martin Parent, Jean‐Martin Beaulieu

The paper identifies and maps D2 receptor expressing neurons in the adult mouse cortex using multimodal techniques, revealing previously uncharacterized clusters and heterogeneity in receptor expression.

Cerebral Cortex · Sep 18, 2018Peer-reviewedNeuroscience