Author

Robert E. Throm

St. Jude Children's Research HospitalORCID 0000-0002-9191-4742Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Francesca FerraraiD· 2 shared Shondra M. Pruett‐MilleriD· 2 shared Adeleye Oluwatosin AdeshakiniD· 1 shared Andrew N. Nemecek· 1 shared Anoop Murthy KavirayaniiD· 1 shared Anthony A. HighiD· 1 shared Ben YoungbloodiD· 1 shared Bradley T. Stevens· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Francesca FerraraORCID

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Author profile →

3 papers

Recent·Most cited

Myogenic and neural transcriptional circuitry determines PAX3::FOXO1 driven initiation of rhabdomyosarcoma

Bradley T. Stevens, Yang Zhang, Matthew R. Garcia, Jack D. Hopkins, Frank S. Wilbanks, Muna N. Ogwo, Shaina N. Porter, Brooke B. Carter, Edwin D. Mathew, Kyna Vuong, Hanna Y. Gebremichael, Uma Neelakantan, Sashi Mandava, Randolph K. Larsen, Francesca Ferrara, , Mark E. Hatley

This study uses a PAX3::FOXO1 inducible model to show P3F initiates ARMS transformation but is not required for maintaining proliferation or transcriptional programs.

bioRxiv · Oct 29, 2026 · PreprintCancer Biology

Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets

Xiao Li, MaryEllen Haas, Dennis Voronin, Rikshita Bhattacharyya, Jonathon Klein, Woo Jung Cho, Camenzind G. Robinson, Robert E. Throm, Gang Wu, Chang Li, Yadav Sapkota, Natalie M. Niemi, Shondra M. Pruett‐Miller, Joseph T. Opferman, Chi‐Lun Chang

This study identifies OPA1's role in fatty acid release from lipid droplets and links its function to human metabolism.

bioRxiv · Oct 18, 2026 · PreprintCell Biology

Reprogramming CAR T-Cells with designed bioPROTACs

Vivek S. Peche, Sebastian Kenny, Tae Gun Kang, Brian Coventry, Tian Mi, Inna Goreshnik, Mariana Garcia Sanchez, Reid Martin, Macey Smith, Dionne K. Vafeados, Rahul S. Kathayat, Kaiwen Yu, Zuo-Fei Yuan, Long Wu, Anthony A. High, , Stephen M Gottschalk

This paper demonstrates that bioPROTACs can reprogram CAR T-cells by targeting DNMT3A, offering a tunable alternative to gene editing for enhancing T-cell function.

bioRxiv · Feb 22, 2026 · PreprintImmunology