IL-13 and IL-17A Activate β1 Integrin through an NF-κB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle
Uyen Thi Ngo, Ying Shi, Prescott G. Woodruff, Kevan M. Shokat, William F. DeGrado, Hyunil Jo, Dean Sheppard, Aparna B. Sundaram
This paper shows IL-13 and IL-17A activate β1 integrins through an NF-κB/Rho kinase/PIP5K1γ pathway, enhancing force transmission in airway smooth muscle and linking this to asthma pathology.
Proceedings of the National Academy of Sciences · Aug 13, 2024Peer-reviewedMolecular Biology