Author

Xiaoyan Guo

UConn HealthORCID 0000-0002-9388-484XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Albert S. SongiD· 1 shared Anette Schneemann· 1 shared Damien ArnoultiD· 1 shared Daniel E. Pride· 1 shared Gabriel C. LanderiD· 1 shared Giovanni AvilesiD· 1 shared Imane Nait IrahaliD· 1 shared Jie YangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Albert S. SongORCID

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2 papers

Recent·Most cited

The Integrated Stress Response Suppresses PINK1-dependent Mitophagy by Preserving Mitochondrial Import Efficiency

Mingchong Yang, Zengshuo Mo, Kelly Walsh, Wen Liu, Imane Nait Irahal, Damien Arnoult, Xiaoyan Guo

This study shows the integrated stress response (ISR) suppresses mitophagy by maintaining mitochondrial import efficiency, independent of ATF4, under non-depolarizing stress.

Nature Communications · Apr 9, 2026Peer-reviewedCell Biology

DELE1 oligomerization promotes integrated stress response activation

Jie Yang, Kelsey R Baron, Daniel E. Pride, Anette Schneemann, Xiaoyan Guo, Wenqian Chen, Albert S. Song, Giovanni Aviles, Martin Kampmann, R. Luke Wiseman, Gabriel C. Lander

This study reports the cryo-EM structure of DELE1's C-terminal fragment, showing its oligomerization and role in activating the integrated stress response.

Nature Structural & Molecular Biology · Aug 7, 2023Peer-reviewedMolecular Biology