Michael J. O’Neill

TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer s disease

This study identifies TREM2-dependent genes and pathways in Alzheimer's disease by analyzing RNA sequencing data from brain samples, revealing its impact on microglia, oligodendrocytes, and endothelial cells.

Deficiency of SYCP3-related XLR3 Disrupts the Initiation of Meiotic Sex Chromosome Inactivation in Mouse Spermatogenesis

This study shows that Xlr3 deficiency disrupts DDR factor recruitment to the XY body, leading to MSCI breakdown and spermatogenic defects in mice.

Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

This study tracks synapse plasticity in tauopathy and finds that changes in synaptic structure precede neurite degeneration, with distinct patterns in axons and dendrites.

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

The paper examines how Aβ plaques develop and affect synaptic density and turnover in a mouse model of Alzheimer's disease, finding an imbalance in pre- and post-synaptic responses.

Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain

This study examines the transcriptional effects of Trem2 loss in mouse brain, revealing disruptions in cell co-expression networks and highlighting a potential role for Trem2 in endothelial cell homeostasis.

Tissue-specific transcriptome for Poeciliopsis prolifica reveals evidence for genetic adaptation related to the evolution of a placental fish.

This study presents a tissue-specific transcriptome of Poeciliopsis prolifica to identify genetic adaptations related to placental evolution in fish.