This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

bioRxiv · Nov 6, 2026 · PreprintPhysiology

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel METZGER, Delphine Duteil

This study shows that glucocorticoid receptor signaling in myeloid cells affects inflammation resolution and muscle repair by regulating macrophage dynamics and satellite cell function.

Advanced Science · Sep 13, 2026Peer-reviewedDevelopmental Biology

Androgen receptor imprints satellite cells stemness and preserves their reservoir for lifelong regeneration and optimal repair

Joe G. Rizk, Kamar C. Ghaibour, Sirine Souali‐Crespo, Emilia Calvano, Aurore Bilger, Hugues Jacobs, Nadia Messaddeq, Qingshuang Cai, Erwan Grandgirard, Rajesh Sahu, Arnaud Ferry, Valentin Fourcade, Joffrey Zoll, Gianni Zanardelli, Nacho Molina, , Delphine Duteil

This study shows androgen receptor signaling maintains skeletal muscle stem cell quiescence and regenerative capacity, and its loss leads to premature activation and stem cell depletion.

Science Advances · Sep 9, 2026Peer-reviewedDevelopmental Biology

Asymmetric inheritance of actin regulatory machinery shapes cytoskeletal heterogeneity during early Caenorhabditis elegans embryogenesis

Grégoire Mathonnet, Roxane Benoit, Delphine Sunher, Nadine Arbogast, Elvire Guiot, Erwan Grandgirard, Anne-Cécile Reymann

This study quantifies actin and related protein segregation during early C. elegans embryogenesis, revealing asymmetric inheritance patterns linked to cell polarity and fate decisions.

bioRxiv · Jul 21, 2026 · PreprintDevelopmental Biology

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion

Junyan Lin, Arantxa Agote‐Arán, Yongrong Liao, Mehdi Cloarec, Leonid P. Andronov, Rafael L. Schoch, Paolo Ronchi, Victor Cochard, Rui Zhu, Erwan Grandgirard, Xiaotian Liu, Marianne Victoria Lemée, Charlotte Kleiss, Christelle Golzio, Marc Ruff, , Izabela Sumara

The paper identifies RanBP2-dependent annulate lamellae as a distinct pathway for nuclear pore assembly and nuclear expansion in somatic cells.

Nature Communications · Mar 25, 2026Peer-reviewedCell Biology

Smart Microscopy: Current Implementations and a Roadmap for Interoperability

Lucien Hinderling, Hannah S. Heil, Alfredo Rates, Philipp Seidel, P. S. Kesavan, Manuel Gunkel, Benedict Diederich, Thomas Guilbert, Rémy Torro, Otmane Bouchareb, Claire Déméautis, Célia Martin, Scott Brooks, Evangelos Sisamakis, Erwan Grandgirard, , Rafael Camacho

This paper reviews current smart microscopy implementations and proposes a framework for interoperability to improve collaboration and standardization in the field.

Methods in microscopy · Feb 21, 2026Peer-reviewedCell Biology

Loss of NR5A1 in Sertoli cells after sex determination changes their cellular identity and induces their death by anoikis

Sirine Souali‐Crespo, Diana Condrea, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Erwan Grandgirard, Violaine Alunni, Marie Cerciat, Matthieu Jung, Chloé Mayère, Serge Nef, Manuel P. Mark, Frédéric Chalmel, Norbert B. Ghyselinck

This study shows that loss of NR5A1 in Sertoli cells after sex determination leads to their transdifferentiation, anoikis, and testis abnormalities.

bioRxiv · Jan 4, 2023 · PreprintDevelopmental Biology