Amanda Nancy Sferruzzi-Perri

Placental lipid handling, growth and inflammatory pathways are modified by a maternal Mediterranean diet

This study examines how a maternal Mediterranean diet affects placental lipid composition and signaling pathways, linking dietary patterns to placental metabolic function and pregnancy outcomes.

Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice

This study shows that maternal colonization with Bifidobacterium breve during pregnancy alters fetal brain metabolism and expression of key pathways.

Fetal manipulation of maternal metabolism is a critical function of Igf2 imprinting

This study shows that Igf2 imprinting in mouse placental endocrine cells is critical for fetal manipulation of maternal metabolism, leading to nutrient allocation and offspring metabolic health outcomes.

Maternal and intrauterine influences on feto-placental growth are accompanied by sexually dimorphic changes in placental mitochondrial respiration, and metabolic signalling pathways

This study shows that maternal and intrauterine environments affect feto-placental growth and placental mitochondrial function differently in male and female fetuses.

Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse.

This study shows that loss of imprinting at the Igf2-H19 ICR1 in mouse placental endocrine junctional zone leads to sex-specific changes in signaling pathways affecting endocrine capacity.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

This study shows that the imprinted Igf2-Igf2r axis is essential for coordinating placental microvasculature expansion with fetal growth in mice.

Placental structure, function and mitochondrial phenotype relate to fetal size and sex in mice

The paper examines how placental mitochondrial function and structure differ between lightest and heaviest fetuses in mice, with sex-specific effects on gene expression and metabolic pathways.

Fetal and trophoblast PI3Kp110α have distinct roles in regulating resource supply to the growing fetus

This study investigates the distinct roles of fetal and trophoblast PI3Kp110α in regulating nutrient supply to the fetus, showing differential effects on placental function and fetal growth.

C-terminal truncation of Pik3r1 in mice models human lipodystrophic insulin resistance uncoupled from dyslipidemia

This study creates a mouse model of SHORT syndrome by introducing a Pik3r1 mutation, revealing lipodystrophic insulin resistance without dyslipidemia.