Author

Chen‐Hsiang Shen

National Institutes of HealthORCID 0000-0002-9560-3992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Assay:protein sequence· 1

Frequent Co-Authors

John R. MascolaiD· 3 shared Nicole A. Doria-RoseiD· 3 shared Peter D. KwongiD· 3 shared Reda RawiiD· 3 shared Baoshan ZhangiD· 2 shared Gwo‐Yu ChuangiD· 2 shared Jing ZhouiD· 2 shared Krisha McKee· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioinformatics

John R. MascolaORCID

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3 papers

Recent·Most cited

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

Hongying Duan, Joseph P. Nkolola, Shuishu Wang, Jayeshbhai Chaudhari, I‐Ting Teng, Christy L. Lavine, Danealle K. Parchment, George S. Sellers, Krisha McKee, Sijy J. O'Dell, Misook Choe, Haijuan Du, Baoshan Zhang, Alejandro A. Espinosa Perez, Annika Rössler, , Dan H. Barouch

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

Cell Reports · Jan 29, 2026Peer-reviewedImmunology

Accurate Prediction of Antibody Resistance in Clinical HIV-1 Isolates

Reda Rawi, Raghvendra Mall, Chen‐Hsiang Shen, S. Katie Farney, Andrea R. Shiakolas, Jing Zhou, Halima Bensmail, Tae‐Wook Chun, Nicole A. Doria‐Rose, Rebecca M. Lynch, John R. Mascola, Peter D. Kwong, Gwo‐Yu Chuang

The paper develops machine learning classifiers to predict HIV-1 resistance to 33 neutralizing antibodies with 96% accuracy using clinical isolates.

Scientific Reports · Oct 11, 2019Peer-reviewedBioinformatics

Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

Gwo‐Yu Chuang, Jing Zhou, Reda Rawi, Chen‐Hsiang Shen, Zizhang Sheng, Anthony P. West, Baoshan Zhang, Tongqing Zhou, Robert T. Bailer, Nicole A. Doria‐Rose, Mark K. Louder, Krisha McKee, John R. Mascola, Pamela J. Björkman, Lawrence S. Shapiro, Peter D. Kwong

The paper analyzes HIV-1 broadly neutralizing antibodies to classify epitopes and identify potential vaccine candidates based on structural and immunological features.

bioRxiv · May 2, 2018 · PreprintBioinformatics