John R. Mascola

Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells

The paper identifies distinct follicular helper CD4 T cell programming in HIV-positive individuals who produce broadly neutralizing antibodies, linking it to improved B cell follicle architecture and reduced suppressor cells.

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized mice

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

Novel HIV-1 fusion peptide immunogens using glycan-engineered alphavirus-like particles

This paper develops glycan-engineered alphavirus-like particles as HIV-1 fusion peptide immunogens, showing improved antibody responses and neutralization against multi-clade HIV-1.

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Accurate Prediction of Antibody Resistance in Clinical HIV-1 Isolates

The paper develops machine learning classifiers to predict HIV-1 resistance to 33 neutralizing antibodies with 96% accuracy using clinical isolates.

Structural survey of HIV-1-neutralizing antibodies targeting Env trimer delineates epitope categories and suggests vaccine templates

The paper analyzes HIV-1 broadly neutralizing antibodies to classify epitopes and identify potential vaccine candidates based on structural and immunological features.