This study identifies auxin-induced interaction between AFB1 receptor and CNGC14 calcium channel, revealing a novel mechanism for calcium influx and growth inhibition in plants.

bioRxiv · Jul 10, 2026 · PreprintPlant Biology

Evolutionary origin of terpenoid biosynthesis in termites

Natan Horáček, Ondřej Lukšan, Zarley Rebholz, Karel Harant, Radek Pohl, Lana Mutabdžija, Simon Hellemans, Daniel Jungwirth, Jan Křivánek, Anna Amirianová, Pavlína Kyjaková, Thomas Bourguignon, Dorothea Tholl, Robert Hanus, Jitka Štáfková

This study identifies a gene family in termites responsible for terpenoid biosynthesis, revealing evolutionary mechanisms and functional enzymes involved in producing diverse terpenoids.

bioRxiv · Jan 30, 2026 · PreprintBiochemistry

Post-transcriptional control of enamel matrix mineralization by TENT5A-mediated cytoplasmic polyadenylation

Goretti Aranaz Novaliches, Olga Gewartowska, František Špoutil, Seweryn Mroczek, Pavel Talacko, Karel Harant, Ana-Matilde Augusto-Vale, Irena Krejzova, Carlos Eduardo Madureira Trufen, Paweł Szczepan Krawczyk, Aleš Benda, Vendula Novosadová, Radislav Sedláček, Andrzej Dziembowski, Jan Procházka

This study shows TENT5A polyadenylates enamel matrix protein mRNAs, enhancing their stability and translation, which is essential for proper enamel mineralization.

bioRxiv · Dec 10, 2025 · PreprintDevelopmental Biology

Phenotype of mice carrying an NMDA receptor GluN2B protein-truncating variant associated with intellectual disability

Klevinda Fili, Viktor Kuchtiak, Eni Tomović, Miriam Candelas, Agnieszka Kubik‐Zahorodna, Karel Harant, Paulína Božíková, Jiří Černý, Miloslav Kořı́nek, Barbora Hrčka Krausová, Vera Abramova, Mark Dobrovolski, Fatma Elzahraa S. Abdel Rahman, Jan Procházka, Aleš Balík, , Ladislav Vyklický

This study characterizes a mouse model with a GluN2B protein-truncating variant, showing reduced NMDAR function and moderate behavioral effects.

bioRxiv · Oct 2, 2025 · PreprintNeuroscience

Entamoeba histolytica extracellular vesicles drive pro-inflammatory monocyte signaling

Barbara Honecker, Valentin A. Bärreiter, Katharina Höhn, Balázs Horváth, Karel Harant, Nahla Galal Metwally, Claudia Marggraff, Juliett Anders, Stephanie Leyk, Maria del Pilar Martinez Tauler, Annika Bea, Charlotte Sophie Hansen, Helena Fehling, Melanie Lütkemeyer, Stephan Lorenzen, , Iris Bruchhaus

This study shows that extracellular vesicles from Entamoeba histolytica drive pro-inflammatory monocyte signaling, contributing to male-biased immunopathology in amebic liver abscesses.

PLoS neglected tropical diseases · Apr 10, 2025Peer-reviewedImmunology

Nanodomain distribution and function of PIN-FORMED auxin efflux carriers in the plasma membrane of tobacco cells are defined by their interactions with the cell wall

Ayoub Stelate, Kateřina Malínská, Eva Tihlaříková, Karel Müller, Roberta Vaculíková, Martina Knirsch, Zuzana Vondráková, Erik Vlčák, Katarzyna Retzer, Michaela Neubergerová, Roman Pleskot, Karel Harant, Vlada Filimonenko, Kateřina Schwarzerová, Vilém Neděla, Jan Petrášek

bioRxiv · Jan 23, 2025 · PreprintPlant Biology

Predicting Blomia tropicalis allergens using a multiomics approach

Jan Hubert, Susanne Vrtala, Bruno Sopko, Scot E. Dowd, Qixin He, Pavel B. Klimov, Karel Harant, Pavel Talacko, Tomáš Erban

This paper uses a multiomics approach to identify and predict allergens in Blomia tropicalis, revealing novel allergens and showing gene expression does not strictly correlate with protein abundance.

Clinical and Translational Allergy · Oct 1, 2023Peer-reviewedMolecular Biology