This study shows that ghrelin and relamorelin reduce hypoglycaemia in humanised mice with KATPHI by enhancing glucose levels, especially when combined with octreotide.

bioRxiv · Oct 2, 2025 · PreprintPhysiology

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

Vikash Chandra, Hazem Ibrahim, Clémentine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimäki‐Vire, Hossam Montaser, Tom Barsby, Väinö Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, , Timo Otonkoski

This study shows that TYK2 is critical for β-cell development by regulating KRAS and IFN responses, suggesting TYK2 inhibition as a therapeutic target for type 1 diabetes.

Nature Communications · Oct 26, 2022Peer-reviewedMolecular Biology

Functional, metabolic and transcriptional maturation of stem cell derived beta cells

Diego Balboa, Tom Barsby, Väinö Lithovius, Jonna Saarimäki‐Vire, Muhmmad Omar‐Hmeadi, Oleg Dyachok, Hossam Montaser, Per-Eric Lund, Mingyu Yang, Hazem Ibrahim, Anna Näätänen, Vikash Chandra, Helena Vihinen, Eija Jokitalo, Jouni Kvist, , Timo Otonkoski

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.

Nature Biotechnology · Mar 3, 2022Peer-reviewedDevelopmental Biology