Isabella Artner

HOXB6 and HOXB8 control immune-cancer cell interactions in pancreatic cancer.

This study identifies HOXB6 and HOXB8 as regulators of immune-cancer cell interactions in pancreatic cancer, showing their role in promoting tumorigenesis and treatment resistance.

Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

This study identifies Hamlet as a key regulator of epithelial tissue fusion in Drosophila reproductive system, revealing its role in gene regulation and tissue connectivity.

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α

This study shows that TYK2 is critical for β-cell development by regulating KRAS and IFN responses, suggesting TYK2 inhibition as a therapeutic target for type 1 diabetes.

Islet Gene View - a tool to facilitate islet research

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.