Nan Zhang

Dissecting shared genetic susceptibility between gastroesophageal reflux disease and psychiatric disorders beyond body mass index

This study identifies shared genetic factors between GERD and psychiatric disorders, showing stronger links with internalizing disorders than with BMI.

Metabolic engineering of Salmonella enterica for coupled kynurenine sensing and depletion enhances antitumor efficacy

This paper engineers Salmonella enterica to sense and deplete kynurenine in tumors, enhancing antitumor immune responses and efficacy in mouse models.

Bacterial endosymbionts enhance fungal virulence by disrupting the disease-suppressive rhizobiome

This study shows bacterial endosymbionts in fungal pathogens enhance virulence by altering the rhizosphere microbiome and reducing disease-suppressive bacteria.

VASP Promotes Aortic Valve Calcification by Interacting with FBLIM1 to Activate the Focal Adhesion Pathway

This study identifies VASP as a key driver of aortic valve calcification through its interaction with FBLIM1 to activate the focal adhesion pathway, promoting calcification and elastin secretion.

Chromatin context-dependent deacetylation by the asymmetric Rpd3L

This study reveals how the Rpd3L complex uses an asymmetric architecture to activate deacetylation in response to chromatin context.

S3R: Modeling spatially varying associations with Spatially Smooth Sparse Regression

S3R models spatially varying associations in spatial transcriptomics data by estimating location-specific coefficients with structured sparsity and smoothness penalties, showing effectiveness in synthetic and real datasets.