Author

Zeynep Yazgan

The University of Texas Southwestern Medical CenterORCID 0009-0002-6902-3692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Huocong HuangiD· 2 shared Kailiang QiaoiD· 2 shared Xiongfeng CheniD· 2 shared Yang LiuiD· 2 shared Yiyue JiaiD· 2 shared Alex C. KimiD· 1 shared Bo ZhangiD· 1 shared Collin GilbreathiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Huocong HuangORCID

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2 papers

Recent·Most cited

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

Kailiang Qiao, Qing‐Lin Yang, Tuo Li, Xiongfeng Chen, Zeynep Yazgan, Yoon Jung Kim, Collin Gilbreath, Jun Yi Stanley Lim, Yipeng Xie, Xiaohui Sun, Yang Liu, Yiyue Jia, Zhijian J. Chen, Huocong Huang, Sihan Wu

This study shows ecDNA-driven oncogene super-expressors create an immunoevasive tumor microenvironment in PDAC by promoting myCAF expansion and suppressing T cell infiltration.

bioRxiv · Nov 15, 2025 · PreprintCancer Biology

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Xiongfeng Chen, Zhuan Zhou, Luyu Xie, Kailiang Qiao, Yiyue Jia, Si Liu, Zeynep Yazgan, Francesca Rossi, Yang Liu, Bo Zhang, Patricio Marcelo Polanco, Herbert J. Zeh, Alex C. Kim, Huocong Huang

Pan-cancer single-cell and spatial profiling resolves two antigen-presenting CAF lineages: tumor-adjacent mesothelial-like apCAFs and tertiary lymphoid structure-associated fibrocyte-like apCAFs, both secreting pro-tumorigenic SPP1.

Cancer Cell · Sep 25, 2025Peer-reviewedCancer Biology✦ In-depth digest