An integrated DNA interactome and transcriptome profiling reveals a PU.1/enhancer RNA-mediated Feed-forward Regulatory Loop Regulating monocyte/macrophage development and innate immune functions
A. S. M. Waliullah, Kevin Qiu, Barbara Dziegielewska, Minh L. Tran, Nicholas N. Nguyen, Leran Wang, Andrew Pan, Natalie Segovia, Simone Ummarino, Junyan Zhang, Tuan M. Nguyen, Jeffrey Craig, Daniel Geoffrey Tenen, Bon Q. Trinh
This study identifies a PU.1/LOUP feed-forward regulatory loop that promotes monocyte/macrophage differentiation and innate immune functions through enhancer RNA-mediated mechanisms.
bioRxiv · Feb 19, 2025 · PreprintMolecular Biology