Gernot Poschet

Disrupting linearity of PROTAC scaffolds prevents off-target complex I inhibition

The paper identifies that linear PROTAC scaffolds inhibit mitochondrial complex I, leading to ATP depletion, and proposes structural modifications to mitigate this off-target effect.

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

WUSCHEL modulates jasmonate signaling to control the balance between growth and defense in the shoot apical meristem

This study shows WUSCHEL modulates jasmonate signaling to control growth-defense balance in the shoot apical meristem during systemic wounding.

MetAlyzer to Perform Streamlined, Interactive, and Pathway-Mapping Analysis of Targeted Metabolomics Data from the biocrates Platform

MetAlyzer streamlines and visualizes targeted metabolomics data from biocrates, enabling interactive analysis without coding.

A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite

This study identifies a metabolism-chromatin axis that regulates ribosome heterogeneity in Plasmodium falciparum during host-to-vector transmission.

Interlaboratory comparison of standardised metabolomics and lipidomics analyses in human and rodent blood using the MxP(R) Quant 500 kit

This study evaluates the interlaboratory reproducibility of the MxP(R) Quant 500 metabolomics/lipidomics kit across human and rodent blood samples, showing high consistency and reliability.

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

This study shows that mitochondrial dysfunction and oxidative stress in Foxp1+/- mice contribute to cognitive and motor impairments in FOXP1 syndrome.