Cristian Saquel

Mechanical stress and caveolin-1 control the release of extracellular vesicles with increased tumorigenic properties

This study shows mechanical stress increases EV release from cancer cells via caveolin-1, leading to more tumorigenic EVs that promote metastasis.

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

This study identifies IGF2 as a disease modifier that reduces intracellular protein aggregates by promoting their extracellular disposal in Huntington's disease models.

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

This study shows that necroptosis mediates axonal degeneration in Parkinson's disease, suggesting it as a targetable pathway.