Dynamins combine mechano-constriction and membrane remodeling to enable two-step mitochondrial fission via a snap-through instability.
Haleh Alimohamadi, Elizabeth Wei-Chia Luo, Xiaoying Liu, Wasi Iqbal, Rena Yang, Shivam Gupta, Kelsey A Nolden, Taraknath Mandal, R. Blake Hill, Liting Duan, Gerard C. L. Wong
This study shows how dynamin proteins use mechano-constriction and membrane curvature to drive mitochondrial fission through a snap-through instability.
Journal of the American Chemical Society · Jul 8, 2025Peer-reviewedBiophysics