Author

Ritu Kumar

Gladstone InstitutesORCID 0000-0002-9995-0078Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Miriam GordilloiD· 2 shared Todd EvansiD· 2 shared Alexey A. SoshneviD· 1 shared Benoit G. BruneauiD· 1 shared Bryce W. Carey· 1 shared C. David AllisiD· 1 shared Daniel QuiatiD· 1 shared Danwei HuangfuiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersDevelopmental Biology

Miriam GordilloORCID

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3 papers

Recent·Most cited

Structural variants in human congenital heart disease disrupt distal genomic regulatory contacts of developmental genes

Jodi Lee, Jingshing Wu, Maureen Pittman, Zoe L. Grant, Shuzhen Kuang, Daniel Quiat, Sarah U. Morton, Geoffrey Fudenberg, Michela Traglia, Kelly Hayes, Ritu Kumar, Benoit G. Bruneau, Katherine S. Pollard

The paper develops a machine-learning model to predict how structural variants disrupt 3D chromatin structure in congenital heart disease and validates its predictions using induced pluripotent stem cells.

bioRxiv · Mar 2, 2026 · PreprintGenomics

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

Joseph A. Bisson, Miriam Gordillo, Ritu Kumar, Neranjan de Silva, Ellen Yang, Kelly M. Banks, Zhong‐Dong Shi, Kihyun Lee, Dapeng Yang, Wendy K. Chung, Danwei Huangfu, Todd Evans

This study shows GATA6 regulates WNT and BMP programs in human precardiac mesoderm patterning, and modulating these pathways can rescue cardiomyocyte defects in GATA6 mutants.

eLife · Mar 13, 2025Peer-reviewedDevelopmental Biology

Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells

Liangwen Zhong, Miriam Gordillo, Xingyi Wang, Yiren Qin, Yuanyuan Huang, Alexey A. Soshnev, Ritu Kumar, Gouri J. Nanjangud, Daylon James, C. David Allis, Todd Evans, Bryce W. Carey, Duancheng Wen

The paper shows that adding lipid-rich albumin to 2i media maintains genomic stability and developmental potency of murine pluripotent stem cells over long-term culture.

bioRxiv · Aug 12, 2022 · PreprintDevelopmental Biology