Mark Eddison

This paper reveals that dopamine release is highly localized to synapse-like structures, challenging the idea that neuromodulators act diffusely.

This paper presents a cross-modal workflow linking in vivo neural activity to molecular cell types using spatial transcriptomics, achieving accurate alignment across thousands of neurons in the mouse dorsal hippocampus.

The paper develops WARP, a platform integrating neuronal activity and gene expression data in zebrafish brains, revealing functional roles of molecularly defined cell populations and their activity correlations.

SpotDMix improves mRNA spot assignment to cells in spatial transcriptomics by using a mixture model and EM algorithm, outperforming simple methods in accuracy and exclusivity.

The paper identifies a novel mechanism for coincidence detection at inhibitory synapses in the Drosophila head direction network involving octopamine-mediated feedback.

The paper introduces WHOLISTIC, a method to image cellular activity across all organs of a vertebrate, revealing body-wide circuits and responses to stimuli.

The paper generates and characterizes split-GAL4 driver lines for specific Drosophila central complex cell types, surveys neuropeptide and receptor expression, and identifies cell types involved in sleep regulation.

The paper introduces morphoFISH, a method combining imaging and spatial transcriptomics to identify new neuronal cell types in the mouse brain.

This study maps cell types and axon projections in the central nucleus of the amygdala using single-cell RNA-sequencing and spatial techniques, revealing distinct molecular and connectivity patterns.

SNT provides a unified framework for neuronal morphometry and single-cell connectomics analysis, integrating with Fiji and ImageJ to support tracing, quantification, and modeling of neuroanatomy.

The paper introduces EASI-FISH, a method for spatial gene expression profiling in thick brain sections, and applies it to discover novel subregions in the lateral hypothalamus.