Author

Bhishem Thakur

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:virus· 1

Frequent Co-Authors

Katarzyna JanowskaiD· 3 shared Priyamvada AcharyaiD· 3 shared Maolin LuiD· 2 shared Revansiddha H. KatteiD· 2 shared Robert J. EdwardsiD· 2 shared Wang XuiD· 2 shared Aaron Cook· 1 shared Advaiti Pai KaneiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Katarzyna JanowskaORCID

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3 papers

Recent·Most cited

Anti-HIV-1 B cell antigen receptor signaling and structure

Bhishem Thakur, Jahangir Alam, Kenneth D. Cronin, Parth Patel, Kara M. Anasti, Advaiti Pai Kane, Alamgir Hossain, Hung Nguyen Do, Katayoun Mansouri, Taylor N. Spence, Robert J. Edwards, Rasangi Pathirage, Katarzyna Janowska, Muralikrishna Lella, Aaron Cook, , S. Munir Alam

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

iScience · Nov 1, 2026Peer-reviewedImmunology

Peptide inhibitors recognize prefusion viral fusion proteins with heterogeneous stoichiometry and rapid kinetics

Revansiddha H. Katte, Junyu Liu, Yufan He, Bhishem Thakur, Xiao Huang, Jared J. Lindenberger, Wang Xu, Narendra Kumar Gonepudi, Yang Han, Katarzyna Janowska, Robert J. Edwards, Priyamvada Acharya, Maolin Lu

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

bioRxiv · Sep 15, 2026 · PreprintMicrobiology

Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening

Bhishem Thakur, Revansiddha H. Katte, Wang Xu, Katarzyna Janowska, Salam Sammour, Rory C. Henderson, Maolin Lu, Peter D. Kwong, Priyamvada Acharya

This study visualizes the conformational changes of the HIV-1 fusion peptide during CD4-induced Env opening, showing it remains antibody accessible despite Env opening.

Nature Communications · May 17, 2025Peer-reviewedMicrobiology