Sarah Gharbi

Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRD

This study compares NuRD's role in human and mouse pluripotent stem cells, finding that NuRD is required for transcriptional responses to differentiation signals in both, but with distinct functional differences between species.

Subunit redundancy within the NuRD complex ensures fidelity of ES cell lineage commitment

The paper shows that MTA proteins in ES cell NuRD complex are functionally redundant, and NuRD is essential for maintaining differentiation trajectory during early lineage commitment.

Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cells

This study shows Sall4 maintains the gene regulatory network in ICM cells before lineage commitment, enabling efficient progression to epiblast or primitive endoderm.

The Nucleosome Remodelling and Deacetylation complex restricts Mediator access to enhancers to control transcription

This study shows the NuRD complex regulates enhancer chromatin structure and Mediator access to control transcription during lineage commitment in ES cells.