Nnennaya Kanu

Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma

This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.

Copy number-aware deconvolution of tumor-normal DNA methylation profiles

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.

Cisplatin is more mutagenic than carboplatin or oxaliplatin at equitoxic concentrations

This study compares the mutagenicity of cisplatin, carboplatin, and oxaliplatin at equitoxic concentrations using whole genome sequencing and phenotypic assays, finding cisplatin induces more mutations and DNA damage.