Emma M. Briggs

This study uses single-cell transcriptomics to analyze life cycle and cell cycle gene expression dynamics in two Leishmania species during in vitro growth, revealing developmental endpoints and cell cycle-related gene expression patterns.

This study shows that Trypanosoma congolense expresses multiple Variant Surface Glycoprotein genes in single cells, unlike Trypanosoma brucei, which uses monoallelic transcription.

TrAGEDy aligns gene expression trajectories from different biological processes without integration, improving detection of biologically relevant genes in T cells and Trypanosoma brucei.

This study identifies cryptic stumpy-like T. brucei forms in cattle with low parasitaemia, challenging rodent-based assumptions about stumpy form differentiation.

This study shows that R-loops and RNase H1 regulate DNA replication timing and genome stability in Leishmania, linking R-loop homeostasis to chromosome size and replication order.

paraCell provides an interactive tool for analyzing and visualizing host-parasite single-cell RNA-Seq data without requiring programming skills.

This study uses Nanopore sequencing to show that DNA replication compartmentalization in Trypanosoma brucei affects genome stability and instability by influencing VSG gene recombination and chromosome stability.

The paper maps R-loop activities across the genome of Trypanosoma brucei, revealing conserved and novel roles in transcription and genome dynamics.