Qiao‐Ling Cui

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

This study shows that TNF and IFNγ inhibit human OPC differentiation into oligodendrocytes and promote an astrocyte-like reactive phenotype, potentially contributing to impaired myelin repair in MS.

The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.

This paper develops a deep learning method to quantify oligodendrocyte ensheathment in vitro, achieving accuracy comparable to human experts and enabling high-throughput analysis.