Min Ni

Metabolic landscape of inborn errors of metabolism

This study uses metabolomics to analyze 474 subjects with inborn errors of metabolism, identifying genotype-specific metabolic alterations and providing diagnostic tools and a database of metabolomic features.

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

Carbohydrate adaptation drives liver-brain axis maturation

The paper shows that LACTB2 in the liver regulates mitochondrial maturation to coordinate carbohydrate metabolism with brain development in mice.

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis

This study shows that somatic mtDNA mutations affect metabolic plasticity in leukemia development, with heterozygous mutations supporting NMyc-driven leukemia while homozygous mutations impair it.

An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism

The paper introduces a web application for exploring metabolomics data from plasma and fibroblasts of patients with inborn errors of metabolism, enabling analysis of metabolic deviations and relationships.

Interrogation of Enhancer Function by Enhanced CRISPR Epigenetic Editing

This paper introduces enhanced CRISPR epigenetic editing systems to analyze enhancer function in vivo, showing improved modulation of gene transcription with minimal off-target effects.