David H. Kwan

This study uses biosensor-guided CRISPR screens in yeast to identify genetic targets that enhance production of cis,cis-muconic acid and protocatechuic acid.

This paper introduces a fluorescence-based enzyme cascade assay to detect NAD(P)H-dependent oxidoreductase activity with significantly higher sensitivity than traditional absorbance methods.

This paper characterizes the PcaR transcription factor, solving its crystal structures and demonstrating its function as a dicarboxylic acid biosensor in yeast.

This paper engineers a TetR-type repressor to recognize multiple aromatic inducers and demonstrates its use in both prokaryotic and eukaryotic systems.