Author

Mackenzie Thornbury

Concordia UniversityORCID 0009-0001-2235-4374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:yeast· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Adrien KnoopsiD· 3 shared Vincent J. J. MartiniD· 3 shared Malcolm S. WhitewayiD· 2 shared Angela Tsai· 1 shared Caroline GuinardiD· 1 shared Craig McCormickiD· 1 shared David Burke James MahoneyiD· 1 shared David H. KwaniD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersSynthetic Biology

Adrien KnoopsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintNov 3, 2026

Biosensor-guided genome-wide CRISPR screens enable cis,cis-muconic acid overproduction in yeast

Mohamed A. Nasr, Adrien Knoops, Mackenzie Thornbury…·Vincent J.J. Martin

This study uses biosensor-guided CRISPR screens in yeast to identify genetic targets that enhance production of cis,cis-muconic acid and protocatechuic acid.

DOI 10.64898/2026.10.31.762157

yeastCRISPR screen

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedNov 24, 2025

Tri-Functional CRISPR Screen Reveals Overexpression of QDR2 and QDR3 Transporters Increase Fumaric Acid Production in Kluyveromyces marxianus

Mackenzie Thornbury, Raha Parvizi Omran, Lalit Kumar…·Vincent J. J. Martin

The paper uses a trifunctional CRISPR screen to identify gene perturbations that enhance fumaric acid tolerance and production in Kluyveromyces marxianus.

1 citation

yeastCRISPR screen

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedJul 8, 2025

Sequencing of a dairy isolate unlocks Kluyveromyces marxianus as a host for lactose valorization

Mackenzie Thornbury, Adrien Knoops, Iain Summerby-Murray…·Vincent J. J. Martin

This study sequences and annotates the genome of Kluyveromyces marxianus Y-1190, identifies genetic factors for lactose metabolism, and develops tools for genetic manipulation to enhance its use in industrial biotechnology.

3 citations

yeastwhole-genome sequencing

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintJul 18, 2018

Discovery and Characterization of Novel Lignocellulose-Degrading Enzymes from the Porcupine Microbiome by Synthetic Metagenomics

Mackenzie Thornbury, Jacob Sicheri, Caroline Guinard…·Craig McCormick

The paper identifies and characterizes four novel lignocellulose-degrading enzymes from the porcupine microbiome and explores their potential for biofuel production.

2 citations

mousemetagenomics

𝕏 PostBluesky