Wenyi Zheng

This study identifies TSPAN3 as a marker of a distinct secretory multivesicular body population with unique trafficking and EV composition compared to CD63-positive compartments.

This study develops an engineered extracellular vesicle platform that improves shRNA loading and delivery efficiency, achieving robust gene silencing in multiple cell types and the mouse brain.

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

This study investigates N-acetylcysteine amide (NACA) as a prophylactic treatment for acute GvHD in a mouse model, showing reduced disease severity and improved survival without affecting donor engraftment.

This study shows that N-acetylcysteine amide (NACA) reduces cyclophosphamide-induced endothelial damage in mice by decreasing apoptosis, oxidative stress, and restoring nitric oxide synthase function.

This paper introduces a method to map EV surfaceomes and target cells using APEX2 proximity labeling on EVs, revealing novel EV-sorting domains.

The paper identifies 24 novel scaffold proteins with conserved EV-sorting abilities, outperforming CD63 in cargo loading and demonstrating improved EV engineering potential.