This study shows that structured alignment of cardiomyocytes improves mitochondrial function and bioenergetic efficiency, highlighting the role of cellular organization in heart health.

Communications Biology · Oct 9, 2025Peer-reviewedCell Biology

Nicotinamide riboside: A promising therapy for MI-induced acute kidney injury by upregulating nicotinamide phosphoribosyltransferase-mediated NAD levels

Nada J. Habeichi, Ghadir Amin, Solène Emmanuelle Boitard, Cynthia Tannous, Rana Ghali, Iman Momken, Reine Diab, George W. Booz, Mathias Mericskay, Fouad Anthony Zouein

This study shows that nicotinamide riboside (NR) improves kidney function and reduces damage in mice after myocardial infarction by increasing NAD levels via NAMPT.

Journal of the American Heart Association · Feb 26, 2025Peer-reviewedPharmacology & Toxicology

A cocktail of B vitamins with nicotinamide riboside, folate and cobalamin preserves cardiac function and mitochondrial oxidative capacities in a mouse model of heart failure.

Solène Emmanuelle Boitard, Morgane Delouche, Ahmed Karoui, Mélanie Gressette, Iman Momken, Bertrand Bouchard, Françoise Mercier‐Nomé, Apolline Imbard, Christophe Lemaire, Anne Garnier, Matthieu Ruiz, Mathias Mericskay, Jérôme Piquereau

This study shows that a B vitamin cocktail improves cardiac function and mitochondrial health in a mouse heart failure model, with sex-specific effects.

bioRxiv · Feb 18, 2025 · PreprintPhysiology