Author

Zhiyong Lou

Tsinghua UniversityORCID 0000-0003-2728-881XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alma L. BurlingameiD· 1 shared Annelies StevaertiD· 1 shared Barbara SeliskoiD· 1 shared Benjamin Van LoyiD· 1 shared Bert VanmecheleniD· 1 shared Bingying WangiD· 1 shared Bruno CanardiD· 1 shared Bruno Ribeiro de Castro Ramos· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCell Biology

Alma L. BurlingameORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 29, 2026

Mechanistic insights into coronavirus inhibition by a distinct base-modified adenosine analog targeting the viral polymerase

Nikolai Bakirtzoglou, Barbara Selisko, Yucen Huang…·Annelies Stevaert

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

DOI 10.64898/2026.10.28.761875

experimental assay

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BioengineeringbioRxivPreprintJun 26, 2026

Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization

X T Wang, Guanying Zhang, Mingda Hu…·Xiangyang Chi

This paper develops AENCS to engineer antibodies targeting glycosylated epitopes, demonstrating ACC01's 24-fold improved neutralization against SARS-CoV-2 variants.

DOI 10.64898/2026.06.25.734658

virusproteomics

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Cell BiologyCell ReportsPeer-reviewedJun 1, 2026

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

Zhijian Ji, Henry De Belly, Taruna Pandey…·Dengke K. Ma

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

DOI 10.1016/j.celrep.2026.117489

C. eleganshuman

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